Abstract Background The upregulated expression of the JAK/STAT pathway promotes tumor growth in Hodgkin lymphoma (HL) and primary mediastinal large B-cell lymphoma (PMBCL).Based on the hypothesis that JAK2 is a therapeutic target, we performed a prospective pilot study using ruxolitinib.Methods Relapsed or refractory patients with HL or PMBCL were

Corrugated metal pipes (CMPs) have been used as culverts in North America since the 1950s.Today, corrosion of CMPs is a major problem that requires an urgent and efficient solution to retrofit thousands of corroded CMPs across the country.One potential solution gaining wide acceptance is to use a fit-in Glass Fiber Reinforced Polymer (GFRP) liner i

Land-use and land-cover (LULC) themes are important for many domains, especially when they process environmental and socio-economic phenomena.The evolution of a land-use database called Open Land Use (OLU) started in 2013 and read more was continued by adapting many user requirements.The goal of this study was to design a new version of the OLU dat

Respiratory syncytial virus (RSV) causes a significant burden of acute respiratory illness across all ages, particularly for infants and older adults.Infants, especially those born prematurely or with underlying health conditions, face a high risk of severe RSV-related lower respiratory tract infections (LRTIs).Globally, RSV contributes to millions

This paper deals with the effect of microstructure condition on ignition temperature, mechanical and corrosion properties of commercial WE43 alloy prepared by various processing techniques tillman 750m including conventional casting, extrusion, and powder metallurgy methods such as spark plasma sintering.For different processing technique, differen